O'Halloran Lab

Department of Biological Sciences at The George Washington University

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Research

2021 to now

Comparative transcriptomics from intestinal cells of permissive and non-permissive hosts during Ancylostoma ceylanicum infection reveals unique signatures of protection and host specificity

Langeland et al., In Press

Culturing and Genetically Manipulating Entomopathogenic Nematodes

Heryanto et al., 2022

Database of glutamate gated chloride (GluCl) subunits across 125 nematode species: patterns of gene accretion and sequence diversification

O'Halloran, 2021

Pan-Phylum Genome-Wide Identification of Sodium Calcium Exchangers Reveal Heterogeneous Expansions and Possible Roles in Nematode Parasitism

Bode and O'Halloran, 2021

CRISPR-PN2: a flexible and genome-aware platform for diverse CRISPR experiments in parasitic nematodes

O'Halloran, 2021

The diversity of ABC transporter genes across the Phylum Nematoda

Langeland et al., 2021

Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora

Motaher et al., 2021

Considerations for anthelmintic resistance emergence in hookworm at a single locus

O'Halloran, 2021

Secreted virulence factors from Heterorhabditis bacteriophora highlight its utility as a model parasite among Clade V nematodes

Kenney et al., 2021
2018 to 2020

NemChR-DB: a database of parasitic nematode chemosensory G-Protein Coupled Receptors

Langeland et al., 2020

A putative lysozyme and serine carboxypeptidase from Heterorhabditis bacteriophora show differential virulence capacities in Drosophila melanogaster

Kenney et al., 2020

A putative UDP-glycosyltransferase from Heterorhabditis bacteriophora suppresses antimicrobial peptide gene expression and factors related to ecdysone signaling

Kenney et al., 2020

Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in GPCR diversity associated with the onset of parasitism

Bernot et al., 2020

Simulation model of CA1 pyramidal neurons reveal opposing roles for the Na+/Ca2+ exchange current and Ca2+ activated K+ current during spike-timing dependent synaptic plasticity

O'Halloran, 2020

Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing

O'Halloran, 2020

Heterorhabditis bacteriophora Excreted-Secreted Products Enable Infection by Photorhabdus luminescens Through Suppression of the Imd Pathway

Kenney et al. 2019

An inducible model of human amylin overexpression reveals diverse transcriptional changes

Aldras et al. 2019

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum

Kitchen et al. 2019

Genome aware CRISPR gRNA target prediction for parasitic nematodes

O'Halloran 2019

NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family

Bode and O'Halloran, 2018

Refined ab initio gene predictions of Heterorhabditis bacteriophora using RNA-seq

Vadnal et al. 2018
2015 to 2017

Identifiication of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora

Vadnal et al. 2017

The NCLX-type Na+/Ca2+exchanger NCX-9 is required for patterning of neural circuits in Caenorhabditis elegans

Sharma et al. 2017

Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans

O'Halloran et al. 2017

fastQ_brew: module for analysis, preprocessing, and reformatting of FASTQ sequence data

O'Halloran, D.M. 2017

phylo-node: A Molecular Phylogenetic Toolkit using Node.js

O'Halloran, D.M. 2017

STITCHER 2.0: primer design for overlapping PCR applications

O'Halloran et al. 2017

A Guide to Using STITCHER for Overlapping Assembly PCR Applications. In: Methods in Molecular Biology, Vol. 1472, Randall Hughes (Ed.): Synthetic DNA. Springer Press

O'Halloran, D.M. 2017

NemaCount: quantification of nematode chemotaxis behavior in a browser

O'Halloran, D.M. 2016

PrimerMapper: high throughput primer design and graphical assembly for PCR and SNP detection

O'Halloran, D.M. 2016

RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora

Ratnappan et al. 2016

The cyclic nucleotide gated channel subunit CNG-1 instructs behavioral outputs in Caenorhabditis elegans by coincidence detection of nutritional status and olfactory input

He et al. 2016

Nematode Sodium Calcium Exchangers: A Surprising Lack of Transport

Sharma and O'Halloran. 2016

STITCHER: A web resource for high-throughput design of primers for overlapping PCR applications

O'Halloran, D.M. 2015

PrimerView: high-throughput primer design and visualization

O'Halloran, D.M. 2015
2012 to 2014

Analysis of the Na+/Ca2+ exchanger gene family within the phylum Nematoda

He and O'Halloran. 2014

Recent structural and functional insights into the family of sodium calcium exchangers

Sharma and O'Halloran. 2014

A Practical Guide to Phylogenetics for Nonexperts

O'Halloran, D.M. 2014

A comparative study into the molecular evolution of conserved signaling pathway members across olfactory, gustatory, and photo-sensory modalities

He et al. 2013

GCY-8, PDE-2 and NCS-1 are Critical Elements of the cGMP-dependent Thermotransduction Cascade in the AFD Neurons Responsible for C. elegans Thermotaxis

Wang et al. 2013

Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans

Sharma et al. 2013

Nuclear PKG localization is regulated by Go alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans

He and O'Halloran. 2013

Cell- and subunit-specific mechanisms of CNG channel ciliary targeting and localization in C. elegans

Wojtyniak et al. 2013

Defining specificity determinants of cyclic GMP-mediated gustatory sensory transduction in Caenorhabditis elegans

Smith et al. 2013

Investigating the relationship between topology and evolution in a dynamic nematode odor genetic network

Fitzpatrick and O'Halloran. 2012

A Molecular Readout of Long-Term Olfactory Adaptation in C. elegans

He et al. 2012

Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans

O'Halloran et al. 2012
Pre-GWU

Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation

Lee et al. 2010

Regulators of AWC mediated olfactory plasticity in Caenorhabditis elegans

O'Halloran et al. 2009

Olfactory adaptation behavior in Caenorhabditis elegans

O'Halloran and L'Etoile. 2007

Multiple Lineage Specific Expansions within the Guanylyl Cyclase Gene Family

Fitzpatrick et al. 2006

The chemosensory system of Caenorhabditis elegans and other nematodes. In: Chemical ecology: from genes to ecosystems. Marcel Dicke (Ed.). Springer

O'Halloran et al. 2006

The molecular phylogeny of a nematode specific clade of heterotrimeric G-protein subunit genes

O'Halloran et al. 2006

Multiplex PCR for Identification of Seven Streptococcus pneumoniae Serotypes Targeted by a 7-Valent Conjugate Vaccine

O'Halloran, D.M. and Cafferkey, M.T. 2005

Chemoreceptor genes: what can we learn from Caenorhabditis elegans and how we can apply this information to studies on other nematodes?

Burnell and O'Halloran. 2003

An investigation of chemotaxis in the insect parasitic nematode, Heterorhabditis bacteriophora.

O'Halloran and Burnell. 2003

People

Damien O'Halloran

Associate Professor, Biology

Interested in joining?

We are recruiting grad and undergrads

Francesca Pavia

Research Assistant, 2021-2022

Shannen Nicole Ubalde

BS/MS candidate, Biology, 2021-Present

Haley Jetter

BS/MS student, Biology, 2020-2022

Andrea Langeland

Ph.D. candidate, Biology, 2020-Present

Megan Liu

StemShip intern, 2018, 2019

Katrin Bode

Ph.D. candidate, Biology, 2017-Present

Reeham Motaher

Ph.D. student, Biology, 2015-2020

Ramesh Ratnappan

Postdoc, Biology/MITM, 2015-2018

Jonathan Vadnal

Research Assistant, Biology, 2015-2019

Vishal Sharma

Ph.D. student, Biology, 2012-2017

Isabel Uriagereka-Herburger

High-School Senior, 2016-2017

Julia Keegan

Senior Hons Thesis, 2015-2016

David Daniel

Undergraduate, 2014-2016

Yoseph Aldras

Senior Hons Thesis, 2013-2015

Chao He

Research Assistant, 2012-2015

Eric Brzozowski

Undergraduate, 2012-2013

Julian Sacca-Schaeffer

Undergraduate, 2012-2013

Zelda Mendelowitz

Undergraduate, 2012

Teaching

BISC 2220: Developmental Neurobiology

Spring, 3cr

BISC 2320: Neural Circuits and Behavior

Fall, 3cr

B.S. Neuroscience

Dr. O'Halloran is the Director of the Neuroscience Major

Contact Us

O'HALLORAN LAB

Lab Address: SEH 5490, 800 22nd St. N.W.

Office Address: SEH 6000B, 800 22nd St. N.W.

City: Washington DC

E-mail: damienoh[at]gwu[dot]edu


Links:

GWU

Biological Sciences

GitHub